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Title: Pilot study of living donor liver transplantation for patients with HCC exceeding Milan criteria
Author: Llovet i Bayer, Josep Maria
Pavel, Mihai
Rimola, Jordi
Diaz, Maria Alba
Colmenero, Jordi
Saavedra, David
Fondevila Campo, Constantino
Ayuso Colella, Carmen
Fuster Obregón, Josep
Ginès i Gibert, Pere
Bruix Tudó, Jordi
García-Valdecasas Salgado, Juan Carlos
Keywords: Trasplantament hepàtic
Pronòstic mèdic
Càncer de fetge
Hepatic transplantation
Liver cancer
Issue Date: 15-Nov-2017
Publisher: No longer published by Elsevier
Abstract: BACKGROUND & AIMS: A subset of patients with hepatocellular carcinoma (HCC) beyond Milan criteria might obtain acceptable survival outcomes after liver transplantation. Living donor liver transplantation (LDLT) has emerged as a feasible alternative to overcome the paucity of donors. METHODS: In 2001 we started a protocol for LDLT in Child A-B patients with HCC fulfilling a set of criteria - the BCLC expanded criteria- that expanded the conventional indications of transplantation: 1 tumor ≤ 7cm, 5 tumors ≤ 3cm, 3 tumors ≤ 5cm without macrovascular invasion or down-staging to Milan after loco-regional therapies. RESULTS: We present a prospective cohort of 22 patients with BCLC extended indications based on size/number (17) or down-staging (5) treated with LDLT between 2001 and 2014. Characteristics of the patients were as follows: median age: 57yr old; males/female: 20/2, Child-Pugh A/B: 16/6, AFP <100ng/mL: 21. Twelve patients received neo-adjuvant loco-regional therapies. At the time of transplantation, 12 patients had HCC staging beyond Milan criteria and 10 within. Pathological reports showed that 50% exceeded BCLC expanded criteria. Perioperative mortality was 0%. After a median follow up of 81 months, the 1-, 3-, 5- and 10-year survival was 95.5%, 86.4%, 80.2% and 66.8%, respectively. Overall, seven patients recurred (range 9-108 mo), and the 5-y and 10-yr actuarial recurrence rate was of 23.8% and 44,4%, respectively. CONCLUSION: A proper selection of candidates for extended indications of living donor liver transplantation for HCC patients provide survival outcomes comparable t
Note: Versió postprint del document publicat a:
It is part of: Liver Transplantation, 2017
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ISSN: 1527-6465
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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