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http://hdl.handle.net/2445/119018
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DC Field | Value | Language |
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dc.contributor.author | Llovet i Bayer, Josep Maria | - |
dc.contributor.author | Pavel, Mihai | - |
dc.contributor.author | Rimola, Jordi | - |
dc.contributor.author | Diaz, Maria Alba | - |
dc.contributor.author | Colmenero, Jordi | - |
dc.contributor.author | Saavedra Pérez, David | - |
dc.contributor.author | Fondevila Campo, Constantino | - |
dc.contributor.author | Ayuso Colella, Carmen | - |
dc.contributor.author | Fuster Obregón, Josep | - |
dc.contributor.author | Ginès i Gibert, Pere | - |
dc.contributor.author | Bruix Tudó, Jordi | - |
dc.contributor.author | García-Valdecasas Salgado, Juan Carlos | - |
dc.date.accessioned | 2018-01-12T18:55:05Z | - |
dc.date.available | 2018-11-15T06:10:23Z | - |
dc.date.issued | 2017-11-15 | - |
dc.identifier.issn | 1527-6465 | - |
dc.identifier.uri | http://hdl.handle.net/2445/119018 | - |
dc.description.abstract | BACKGROUND & AIMS: A subset of patients with hepatocellular carcinoma (HCC) beyond Milan criteria might obtain acceptable survival outcomes after liver transplantation. Living donor liver transplantation (LDLT) has emerged as a feasible alternative to overcome the paucity of donors. METHODS: In 2001 we started a protocol for LDLT in Child A-B patients with HCC fulfilling a set of criteria - the BCLC expanded criteria- that expanded the conventional indications of transplantation: 1 tumor ≤ 7cm, 5 tumors ≤ 3cm, 3 tumors ≤ 5cm without macrovascular invasion or down-staging to Milan after loco-regional therapies. RESULTS: We present a prospective cohort of 22 patients with BCLC extended indications based on size/number (17) or down-staging (5) treated with LDLT between 2001 and 2014. Characteristics of the patients were as follows: median age: 57yr old; males/female: 20/2, Child-Pugh A/B: 16/6, AFP <100ng/mL: 21. Twelve patients received neo-adjuvant loco-regional therapies. At the time of transplantation, 12 patients had HCC staging beyond Milan criteria and 10 within. Pathological reports showed that 50% exceeded BCLC expanded criteria. Perioperative mortality was 0%. After a median follow up of 81 months, the 1-, 3-, 5- and 10-year survival was 95.5%, 86.4%, 80.2% and 66.8%, respectively. Overall, seven patients recurred (range 9-108 mo), and the 5-y and 10-yr actuarial recurrence rate was of 23.8% and 44,4%, respectively. CONCLUSION: A proper selection of candidates for extended indications of living donor liver transplantation for HCC patients provide survival outcomes comparable t | - |
dc.format.extent | 35 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | No longer published by Elsevier | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/lt.24977 | - |
dc.relation.ispartof | Liver Transplantation, 2017 | - |
dc.relation.uri | https://doi.org/10.1002/lt.24977 | - |
dc.rights | (c) American Association for the Study of Liver Diseases, 2017 | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Trasplantament hepàtic | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.classification | Càncer de fetge | - |
dc.subject.other | Hepatic transplantation | - |
dc.subject.other | Prognosis | - |
dc.subject.other | Liver cancer | - |
dc.title | Pilot study of living donor liver transplantation for patients with HCC exceeding Milan criteria | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 675304 | - |
dc.date.updated | 2018-01-12T18:55:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29140601 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
Files in This Item:
File | Description | Size | Format | |
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675304.pdf | 1.36 MB | Adobe PDF | View/Open |
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