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Title: Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
Author: Wickman, Magnus
Lupinek, Christian
Andersson, Niklas
Belgrave, Danielle
Asarnoj, Anna
Benet, Marta
Pinart Gilberga, Mariona
Wieser, Sandra
García Aymerich, Judith
Baar, Alexandra
Pershagen, Göran
Simpson, Angela
Kull, Inger
Bergstrom, Anna
Melén, Erik
Hamsten, Carl
Antó i Boqué, Josep Maria
Bousquet, Jean
Custovic, Adnan
Valenta, Rudolf
Hage, Marianne van
Keywords: Asma infantil
Malalties de l'aparell respiratori en els infants
Asthma in children
Respiratory diseases in children
Issue Date: 14-Nov-2017
Publisher: Elsevier
Abstract: BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16years. Clinically and independent relevant allergen molecules accounting for >/=90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11years (N=248) and the outcome was studied at 11years. FINDINGS: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to >/=3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16years were 100% and 100%, respectively, for IgE reactivity to >/=3 of 5 risk molecules. INTERPRETATIONS: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.
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It is part of: EBioMedicine, 2017, vol. 26, p. 91-99
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ISSN: 2352-3964
Appears in Collections:Articles publicats en revistes (ISGlobal)

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