Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/119372
Title: Telomere length shows no association with BRCA1 and BRCA2 mutation status
Author: Killick, Emma
Tymrakiewicz, Malgorzata
Cieza-Borrella, Clara
Smith, Paula
Thompson, Deborah J.
Pooley, Karen A.
Easton, Douglas F.
Bancroft, Elizabeth K.
Page, Elizabeth
Leongamornlert, Daniel
IMPACT Study Collaborators
Kote-Jarai, Zsofia
Eeles, Rosalind A.
Blanco Guillermo, Ignacio
Salinas Masdeu, Mònica
Keywords: Telòmer
Proteïnes supressores de tumors
Mutació (Biologia)
Tumors
Càncer de mama
Càncer de pròstata
Telomere
Tumor suppressor protein
Mutation (Biology)
Tumors
Breast cancer
Prostate cancer
Issue Date: 29-Jan-2014
Publisher: Public Library of Science (PLoS)
Abstract: This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 male BRCA1/2 mutation carriers and controls (mean age 53 years), all healthy at time of enrolment and blood donation, 21 of whom have developed prostate cancer whilst on study. The second group consisted of 283 female BRCA1/2 mutation carriers and controls (mean age 48 years), half of whom had been diagnosed with breast cancer prior to enrolment. TL was quantified by qPCR from DNA extracted from peripheral blood lymphocytes. Weighted and unweighted Cox regressions and linear regression analyses were used to assess whether TL was associated with BRCA1/2 mutation status or cancer risk. We found no evidence for association between developing cancer or being a BRCA1 or BRCA2 mutation carrier and telomere length. It is the first study investigating TL in a cohort of genetically predisposed males and although TL and BRCA status was previously studied in females our results don't support the previous finding of association between hereditary breast cancer and shorter TL.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0086659
It is part of: PLoS One, 2014, vol. 9, num. 1, p. e86659
URI: http://hdl.handle.net/2445/119372
Related resource: https://doi.org/10.1371/journal.pone.0086659
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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