Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/119392
Title: | Serum brain-derived neurotrophic factor levels and cocaine-induced transient psychotic symptoms |
Author: | Corominas-Roso, Margarida Roncero, Carlos Eiroá Orosa, Francisco José Ribasés Haro, Marta Barral, Carmen Daigre, Constanza Martínez-Luna, Nieves Sánchez Mora, Cristina Ramos Quiroga, Josep Antoni Casas, Miquel |
Keywords: | Cocaïna Drogoaddicció Psicosi Cocaine Drug addiction Psychoses |
Issue Date: | 2013 |
Publisher: | Karger |
Abstract: | Background: Cocaine-induced psychosis (CIP) is among the most serious adverse effects of cocaine. Reduced serum brain-derived neurotrophic factor (BDNF) levels have been reported in schizophrenia and psychosis; however, studies assessing the involvement of BDNF in CIP are lacking. Methods: A total of 22 cocaine-dependent patients (aged 33.65 ± 6.85) who had never experienced psychotic symptoms under the influence of cocaine (non-CIP) and 18 patients (aged 34.18 ± 8.54) with a history of CIP completed a 2-week detoxification program in an inpatient facility. Two serum samples were collected from each patient at baseline and at the end of the protocol. Demographic, consumption and clinical data were recorded for all patients. A paired group of healthy controls was also included. Results: At the beginning of the detoxification treatment, serum BDNF levels were similar in both the non-CIP and the CIP groups. During early abstinence, the non-CIP group exhibited a significant increase in serum BDNF levels (p = 0.030), whereas the CIP group exhibited a decrease. Improvements in depression (Beck Depression Inventory, BDI, p = 0.003) and withdrawal symptoms (Cocaine Selective Severity Assessment, CSSA, p = 0.013) show a significant positive correlation with serum BDNF levels in the non-CIP group, whereas no correlation between the same variables was found in the CIP group. Conclusions: This study suggests that BDNF plays a role in the transient psychotic symptoms associated with cocaine consumption. In the non-CIP group, the increase in serum BDNF appears to be driven by the effects of chronic cocaine consumption and withdrawal. In contrast, patients with CIP share some of the neurotrophic deficiencies that characterize schizophrenia and psychosis. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1159/000353259 |
It is part of: | Neuropsychobiology, 2013, vol. 68, num. 3, p. 146-155 |
URI: | http://hdl.handle.net/2445/119392 |
Related resource: | https://doi.org/10.1159/000353259 |
ISSN: | 0302-282X |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) |
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