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http://hdl.handle.net/2445/119434
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DC Field | Value | Language |
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dc.contributor.author | Solé Acha, Xavier | - |
dc.contributor.author | Crous Bou, Marta | - |
dc.contributor.author | Cordero Romera, David | - |
dc.contributor.author | Olivares, David | - |
dc.contributor.author | Guinó, Elisabet | - |
dc.contributor.author | Sanz Pamplona, Rebeca | - |
dc.contributor.author | Rodríguez Moranta, Francisco | - |
dc.contributor.author | Sanjuan, Xavier | - |
dc.contributor.author | Oca Burguete, Javier de | - |
dc.contributor.author | Salazar Soler, Ramón | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.date.accessioned | 2018-01-31T09:21:21Z | - |
dc.date.available | 2018-01-31T09:21:21Z | - |
dc.date.issued | 2014-09-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/119434 | - |
dc.description.abstract | Background: accurate detection of characteristic proteins secreted by colon cancer tumor cells in biological fluids could serve as a biomarker for the disease. The aim of the present study was to identify and validate new serum biomarkers and demonstrate their potential usefulness for early diagnosis of colon cancer. Methods: the study was organized in three sequential phases: 1) biomarker discovery, 2) technical and biological validation, and 3) proof of concept to test the potential clinical use of selected biomarkers. A prioritized subset of the differentially-expressed genes between tissue types (50 colon mucosa from cancer-free individuals and 100 normal-tumor pairs from colon cancer patients) was validated and further tested in a series of serum samples from 80 colon cancer cases, 23 patients with adenoma and 77 cancer-free controls.Results: in the discovery phase, 505 unique candidate biomarkers were identified, with highly significant results and high capacity to discriminate between the different tissue types. After a subsequent prioritization, all tested genes (N = 23) were successfully validated in tissue, and one of them, COL10A1, showed relevant differences in serum protein levels between controls, patients with adenoma (p = 0.0083) and colon cancer cases (p = 3.2e-6). Conclusion: we present a sequential process for the identification and further validation of biomarkers for early detection of colon cancer that identifies COL10A1 protein levels in serum as a potential diagnostic candidate to detect both adenoma lesions and tumor. Impact:the use of a cheap serum test for colon cancer screening should improve its participation rates and contribute to decrease the burden of this disease. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0106748 | - |
dc.relation.ispartof | PLoS One, 2014, vol. 9, num. 9, p. e106748 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0106748 | - |
dc.rights | cc-by (c) Solé Acha, Xavier et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Marcadors tumorals | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.other | Tumor markers | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Diagnosis | - |
dc.title | Discovery and validation of new potential biomarkers for early detection of colon cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 649517 | - |
dc.date.updated | 2018-01-31T09:21:21Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25215506 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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649517.pdf | 1.11 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License