Please use this identifier to cite or link to this item:
Title: Burden of invasive pneumococcal disease among children in rural Mozambique: 2001-2012
Author: Sigaúque, Betuel
Verani, Jennifer R.
Massora, Sérgio
Vubil, Delfino
Quintó, Llorenç
Acácio, Sozinho
Mandomando, Inácio
Bassat Orellana, Quique
Nhampossa, Tacilta
Pimenta, Fabiana
Sacoor, Charfudin
Carvalho, Maria da Gloria
Macete, Eusébio
Alonso, Pedro
Keywords: VIH (Virus)
HIV (Viruses)
Issue Date: 5-Jan-2018
Publisher: Public Library of Science (PLoS)
Abstract: BACKGROUND: Invasive pneumococcal disease (IPD) is a major cause of illness and death among children worldwide. 10-valent pneumococcal conjugate vaccine (PCV10) was introduced as part of the Mozambican routine immunization program in April 2013. We characterized the IPD burden in a rural area of Mozambique before PCV introduction and estimated the potential impact of this intervention. METHODS: We conducted population-based surveillance for IPD, defined as S. pneumoniae isolated from blood or cerebrospinal fluid, among children <5 years old admitted to Manhica District Hospital, a referral hospital in a rural area with high prevalence of human immunodiciency virus infection. S. pneumoniae was identified using standard microbiologic methods and serotyped using sequential multiplex PCR or Quellung. IPD incidence was calculated among cases from a defined catchment area. RESULTS: From January 2001 through December 2012, we isolated 768 cases of IPD, 498 (65%) of which were bacteraemic pneumonia episodes. A total of 391 (51%) were from the catchment area, yielding IPD incidence rates of 479, 390 and 107 episodes per 100,000 children-years at risk among children <12, 12-23 and 24-<60 months old, respectively. The overall IPD incidence fluctuated and showed a downward trend over time. In these same age groups, in-hospital death occurred in 48 (17%), 26 (12%), and 21 (13%) of all IPD cases, respectively. Overall 90% (543/603) of IPD isolates were available for serotyping; of those, 65% were covered by PCV10 and 83% by PCV13. Among 77 hospital deaths associated with serotyped IPD, 49% and 69% were caused by isolates included in the PCV10 and PCV13, respectively. CONCLUSIONS: We describe very high rates of IPD among children in rural Mozambique that were declining before PCV introduction. Children <1 year old have the greatest incidence and case fatality; although the rates remain high among older groups as well. Most IPD episodes and many deaths among children <5 years old will likely be prevented through PCV10 introduction in Mozambique.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2018, vol. 13, num. 1, p. e0190687
Related resource:
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (ISGlobal)

Files in This Item:
File Description SizeFormat 
sigauque2018_2868.pdf1.32 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons