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Title: New GABA amides activating GABAa-receptors
Author: Raster, Peter
Späth, Andreas
Bultakova, Svetlana
Gorostiza Langa, Pablo Ignacio
König, Burkhard
Bregestovski, Piotr
Keywords: Receptors de neurotransmissors
Neurotransmitter receptors
Issue Date: 2013
Publisher: Beilstein Institute
Abstract: We have prepared a series of new and some literature-reported GABA-amides and determined their effect on the activation of GABA A -receptors expressed in CHO cells. Special attention was paid to the purification of the target compounds to remove even traces of GABA contaminations, which may arise from deprotection steps in the synthesis. GABA-amides were previously reported to be partial, full or superagonists. In our hands these compounds were not able to activate GABA A -receptor channels in whole-cell patch-clamp recordings. New GABA-amides, however, gave moderate activation responses with a clear structure-activity relation- ship suggesting some of these compounds as promising molecular tools for the functional analysis of GABA A -receptors
Note: Reproducció del document publicat a:
It is part of: Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 406-410
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ISSN: 1860-5397
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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