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http://hdl.handle.net/2445/119678
Title: | Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease |
Author: | Mesquida, Marina Molins Monteys, Blanca Llorenç, Victor Sainz de la Maza Serra, María Teresa Hernandez, Maria Victoria Espinosa Garriga, Gerard Adán Civera, Alfredo |
Keywords: | Citoquines Proteïnes de la sang Uveïtis Malaltia de Behçet Inflamació Cytokines Blood proteins Uveitis Behçet's disease Inflammation |
Issue Date: | 8-Jun-2014 |
Publisher: | Hindawi Publishing Corporation |
Abstract: | The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behcet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-gamma (IFN-gamma), interleukin-1 beta (IL-1 beta), IL-12p70, IL-17A, tumor necrosis factor-alpha (TNF-alpha), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-gamma and TNF-alpha were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-gamma, TNF-alpha, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-gamma, TNF-alpha, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity. |
Note: | Reproducció del document publicat a: https://doi.org/10.1155/2014/396204 |
It is part of: | Mediators of Inflammation, 2014, vol. 2014 |
URI: | http://hdl.handle.net/2445/119678 |
Related resource: | https://doi.org/10.1155/2014/396204 |
ISSN: | 0962-9351 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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