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Title: Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease
Author: Mesquida, Marina
Molins Monteys, Blanca
Llorenç, Victor
Sainz de la Maza, Maite
Hernandez, Maria Victoria
Espinosa Garriga, Gerard
Adán Civera, Alfredo
Keywords: Citoquines
Proteïnes de la sang
Malaltia de Behçet
Blood proteins
Behçet's disease
Issue Date: 8-Jun-2014
Publisher: Hindawi Publishing Corporation
Abstract: The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behcet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-gamma (IFN-gamma), interleukin-1 beta (IL-1 beta), IL-12p70, IL-17A, tumor necrosis factor-alpha (TNF-alpha), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-gamma and TNF-alpha were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-gamma, TNF-alpha, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-gamma, TNF-alpha, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.
Note: Reproducció del document publicat a:
It is part of: Mediators of Inflammation, 2014, vol. 2014
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ISSN: 0962-9351
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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