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DC Field | Value | Language |
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dc.contributor.author | Mesquida, Marina | - |
dc.contributor.author | Molins Monteys, Blanca | - |
dc.contributor.author | Llorenç, Victor | - |
dc.contributor.author | Sainz de la Maza Serra, María Teresa | - |
dc.contributor.author | Hernandez, Maria Victoria | - |
dc.contributor.author | Espinosa Garriga, Gerard | - |
dc.contributor.author | Adán Civera, Alfredo | - |
dc.date.accessioned | 2018-02-08T11:21:49Z | - |
dc.date.available | 2018-02-08T11:21:49Z | - |
dc.date.issued | 2014-06-08 | - |
dc.identifier.issn | 0962-9351 | - |
dc.identifier.uri | http://hdl.handle.net/2445/119678 | - |
dc.description.abstract | The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behcet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-gamma (IFN-gamma), interleukin-1 beta (IL-1 beta), IL-12p70, IL-17A, tumor necrosis factor-alpha (TNF-alpha), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-gamma and TNF-alpha were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-gamma, TNF-alpha, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-gamma, TNF-alpha, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Hindawi Publishing Corporation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1155/2014/396204 | - |
dc.relation.ispartof | Mediators of Inflammation, 2014, vol. 2014 | - |
dc.relation.uri | https://doi.org/10.1155/2014/396204 | - |
dc.rights | cc-by (c) Mesquida, Marina et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Citoquines | - |
dc.subject.classification | Proteïnes de la sang | - |
dc.subject.classification | Uveïtis | - |
dc.subject.classification | Malaltia de Behçet | - |
dc.subject.classification | Inflamació | - |
dc.subject.other | Cytokines | - |
dc.subject.other | Blood proteins | - |
dc.subject.other | Uveitis | - |
dc.subject.other | Behçet's disease | - |
dc.subject.other | Inflammation | - |
dc.title | Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 663786 | - |
dc.date.updated | 2018-02-08T11:21:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24994946 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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663786.pdf | 1.52 MB | Adobe PDF | View/Open |
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