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Title: In vitro comparative skin irritation induced by micro and nano zinc oxide
Author: Vinardell Martínez-Hidalgo, Ma. Pilar
Llanas Marco, Hector
Marics, Laura
Mitjans Arnal, Montserrat
Keywords: Òxid de zinc
Malalties de la pell
Zinc oxide
Skin diseases
Issue Date: 4-Mar-2017
Publisher: MDPI
Abstract: This study was designed to determine whether nano-sized ZnO has the potential to cause acute cutaneous irritation using cultured HaCaT keratinocytes and a human skin equivalent as in vitro models, compared to non-nanomaterials. Commercial nano ZnO with different sizes (50 nm and 100 nm) was characterized by dynamic light scattering (DLS) and microscopy (SEM) in different media. Nano ZnO reduced the cell viability of HaCaT in a dose-dependent and time-dependent manner, in a similar way to macro ZnO. However, the 3D-epidermis model revealed no irritation at 1 mg/mL after 24 h of exposure. In conclusion, nano-sized ZnO does not irritate skin, in a similar manner to non-nano ZnO.
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It is part of: Nanomaterials, 2017, vol. 7, num. 56
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ISSN: 2079-4991
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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