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Title: | The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries |
Author: | McGrath, John J. McLaughlin, K. A. Saha, Sukanta Aguilar-Gaxiola, Sergio Al-Hamzawi, Ali Obaid Alonso, Jordi Bruffaerts, Ronny Girolamo, Giovanni de Jonge, Peter de Esan, O. Florescu, Silvia E. Gureje, Oye Haro Abad, Josep Maria Hu, Chiyi Karam, Elie Georges Kovess-Masfety, Viviane Lee, Soon Yeun Lepine, Jean Pierre Lim, Carmen C. W. Medina Mora, Maria Elena Mneimneh, Z. Pennell, Beth-Ellen Piazza, Marina Posada Villa, José Sampson, Nancy A. Viana, Maria Carmen Xavier, Miguel Bromet, Evelyn J. Kendler, Kenneth S. Kessler, Ronald C. |
Keywords: | Malalties mentals Infants Mental illness Children |
Issue Date: | 9-Jan-2017 |
Publisher: | Cambridge University Press |
Abstract: | Although there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations. METHOD: We assessed CAs, PEs and DSM-IV mental disorders in 23 998 adults in the WHO World Mental Health Surveys. Discrete-time survival analysis was used to investigate the associations between CAs and PEs, and the influence of mental disorders on these associations using multivariate logistic models. RESULTS: Exposure to CAs was common, and those who experienced any CAs had increased odds of later PEs [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.9-2.6]. CAs reflecting maladaptive family functioning (MFF), including abuse, neglect, and parent maladjustment, exhibited the strongest associations with PE onset in all life-course stages. Sexual abuse exhibited a strong association with PE onset during childhood (OR 8.5, 95% CI 3.6-20.2), whereas Other CA types were associated with PE onset in adolescence. Associations of other CAs with PEs disappeared in adolescence after adjustment for prior-onset mental disorders. The population attributable risk proportion (PARP) for PEs associated with all CAs was 31% (24% for MFF). CONCLUSIONS: Exposure to CAs is associated with PE onset throughout the life-course, although sexual abuse is most strongly associated with childhood-onset PEs. The presence of mental disorders prior to the onset of PEs does not fully explain these associations. The large PARPs suggest that preventing CAs could lead to a meaningful reduction in PEs in the population. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1017/S0033291716003263 |
It is part of: | Psychological Medicine, 2017, vol. 47, num. 7 |
URI: | http://hdl.handle.net/2445/120251 |
Related resource: | https://doi.org/10.1017/S0033291716003263 |
ISSN: | 0033-2917 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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