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DC Field | Value | Language |
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dc.contributor.author | Mesquida Estévez, Ma. Neus | - |
dc.contributor.author | López Pérez, Sara | - |
dc.contributor.author | Dinarès Milà, M. Immaculada | - |
dc.contributor.author | Alcalde Pais, Ma. Ermitas (María de las Ermitas) | - |
dc.date.accessioned | 2018-03-08T14:48:22Z | - |
dc.date.available | 2018-03-08T14:48:22Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1860-5397 | - |
dc.identifier.uri | http://hdl.handle.net/2445/120566 | - |
dc.description.abstract | The synthesis of multifunctional indenes with at least two different functional groups has not yet been extensively explored. Among the plausible synthetic routes to 3,5-disubstituted indenes bearing two different functional groups, such as the [3-(aminoethyl)inden-5-yl)]amines, a reasonable pathway involves the (5-nitro-3-indenyl)acetamides as key intermediates. Although several multistep synthetic approaches can be applied to obtain these advanced intermediates, we describe herein their preparation by an aldol-type reaction between 5-nitroindan-1-ones and the lithium salt of N,N-disubstituted acetamides, followed immediately by dehydration with acid. This classical condensation process, which is neither simple nor trivial despite its apparent directness, permits an efficient entry to a variety of indene-based molecular modules, which could be adapted to a range of functionalized indanones. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Beilstein Institute | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3762/bjoc.7.204 | - |
dc.relation.ispartof | Beilstein Journal of Organic Chemistry, 2011, vol. 7, p. 1739-1744 | - |
dc.relation.uri | https://doi.org/10.3762/bjoc.7.204 | - |
dc.rights | cc-by (c) Mesquida Estévez, Ma. Neus et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Síntesi orgànica | - |
dc.subject.classification | Compostos organometàl·lics | - |
dc.subject.classification | Compostos policíclics | - |
dc.subject.classification | Amides | - |
dc.subject.other | Organic synthesis | - |
dc.subject.other | Organometallic compounds | - |
dc.subject.other | Polycyclic compounds | - |
dc.subject.other | Amides | - |
dc.title | Synthetic approaches to multifunctional indenes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 602210 | - |
dc.date.updated | 2018-03-08T14:48:22Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22238553 | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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602210.pdf | 312.18 kB | Adobe PDF | View/Open |
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