Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/120590
Title: Effectiveness of 23-valent pneumococcal polysaccharide vaccination in preventing community-acquired pneumonia hospitalization and severe outcomes in the elderly in Spain
Author: Domínguez García, Àngela
Soldevila, Núria
Toledo, Diana
Torner Gràcia, Núria
Force, Luis
Pérez Lozano, María José
Martín Sánchez, Vicente
Rodríguez Rojas, Lourdes
Astray, Jenaro
Egurrola, Mikel
Sanz, Francisco
Castilla, Jesús
Keywords: Vacunes
Pneumònia
Polisacàrids
Persones grans
Vaccines
Pneumonia
Polysaccharides
Older people
Issue Date: 10-Feb-2017
Publisher: Public Library of Science (PLoS)
Abstract: Pneumococcal pneumonia is a serious cause of morbidity and mortality in the elderly, but investigation of the etiological agent of community-acquired pneumonia (CAP) is not possible in most hospitalized patients. The aim of this study was to estimate the effect of pneumococcal polysaccharide vaccination (PPSV23) in preventing CAP hospitalization and reducing the risk of intensive care unit admission (ICU) and fatal outcomes in hospitalized people aged 65 years. We made a multicenter case-control study in 20 Spanish hospitals during 2013-2014 and 2014-2015. We selected patients aged 65 years hospitalized with a diagnosis of pneumonia and controls matched by sex, age and date of hospitalization. Multivariate analysis was performed using conditional logistic regression to estimate vaccine effectiveness and unconditional logistic regression to evaluate the reduction in the risk of severe and fatal outcomes. 1895 cases and 1895 controls were included; 13.7% of cases and 14.4% of controls had received PPSV23 in the last five years. The effectiveness of PPSV23 in preventing CAP hospitalization was 15.2% (95% CI -3.1-30.3). The benefit of PPSV23 in avoiding ICU admission or death was 28.1% (95% CI -14.3-56.9) in all patients, 30.9% (95% CI -32.2-67.4) in immunocompetent patients and 26.9% (95% CI -38.6-64.8) in immunocompromised patients. In conclusion, PPSV23 showed a modest trend to avoidance of hospitalizations due to CAP and to the prevention of death or ICU admission in elderly patients hospitalized with a diagnosis of CAP.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0171943
It is part of: PLoS One, 2017, vol. 12, num. 2, p. e0171943
URI: http://hdl.handle.net/2445/120590
Related resource: https://doi.org/10.1371/journal.pone.0171943
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)

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