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|Title:||Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germ-cell tumours|
|Author:||Zurita, A. J.|
Diestra, J. E.
Condom i Mundó, Enric
García del Muro Solans, Xavier
Scheffer, G. L.
Scheper, R. J.
Germà Lluch, José Ramón
Izquierdo, M. A.
|Keywords:||Malalties del testicle|
Proteïnes supressores de tumors
Resistència als medicaments
Tumor suppressor protein
|Publisher:||Cancer Research UK|
|Abstract:||This study was undertaken to investigate the expression and predictive value for outcome of multidrug resistance-associated (MDR) proteins P-glycoprotein (Pgp), MRP1, BCRP, and LRP, in advanced testicular germ-cell tumours (TGCT). Paraffin-embedded sections from 56 previously untreated patients with metastatic TGCT were immunostained for Pgp, MRP1, BCRP, and LRP. All patients received platinum-based chemotherapy after orchidectomy. Immunostaining was related to clinicopathological parameters, response to chemotherapy, and outcome. Strong and intermediate expressions of the different MDR-related proteins were: 27 and 41% (Pgp), 54 and 37% (MRP1), 86 and 7% (BCRP), and 14 and 29% (LRP). P-glycoprotein and MRP1 associated, respectively, to low AFP (P=0.026) and high LDH levels (P=0.014), whereas LRP expression associated with high β-hCG levels (P=0.003) and stage IV tumours (P=0.029). No correlation was found between Pgp, MRP1, and BCRP expression and response to chemotherapy and survival. In contrast, patients with LRP-positive tumours (strong or intermediate expression) had shorter progression-free (P=0.0006) and overall survival (P=0.0116) than LRP-negative patients, even after individual log-rank adjustments by statistically associated variables. Our data suggest that a positive LRP immunostaining at the time of diagnosis in metastatic TGCT is associated with an adverse clinical outcome.|
|Note:||Reproducció del document publicat a: https://doi.org/10.1038/sj.bjc.6600803|
|It is part of:||British Journal of Cancer, 2003, vol. 88, num. 6, p. 879-886|
|Appears in Collections:||Articles publicats en revistes (Patologia i Terapèutica Experimental)|
Articles publicats en revistes (Ciències Clíniques)
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