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Title: Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
Author: Muñoz, N.
Hernandez-Suarez, G.
Méndez, F.
Molano, M.
Posso, H.
Moreno Aguado, Víctor
Murillo, R.
Ronderos, M.
Meijer, Chris J.L.M.
Muñoz, Á.
INC HPV Study Group
Keywords: Papil·lomavirus
Vacuna del papil·lomavirus
Coll uterí
Factors de risc en les malalties
Papillomavirus vaccines
Cervix uteri
Risk factors in diseases
Issue Date: 7-Apr-2009
Publisher: Cancer Research UK
Abstract: Little is known about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women >30 years of age. This information is needed to assess the impact of HPV vaccines and consider new screening strategies. A cohort of 1728 women 15-85 years old with normal cytology at baseline was followed every 6 months for an average of 9 years. Women with squamous intraepithelial lesions were referred for biopsy and treatment. The Kaplan-Meier method was used to estimate the median duration of infection and Cox regression analysis was undertaken to assess determinants of clearance and risk of CIN2/3 associated with HPV persistence. No difference in the likelihood of clearance was observed by HPV type or woman's age, with the exception of lower clearance for HPV16 infection in women under 30 years of age. Viral load was inversely associated with clearance. In conclusion, viral load is the main determinant of persistence, and persistence of HPV16 infections carry a higher risk of CIN2/3.
Note: Reproducció del document publicat a:
It is part of: British Journal of Cancer, 2009, vol. 100, num. 7, p. 1184-1190
Related resource:
ISSN: 0007-0920
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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