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http://hdl.handle.net/2445/120949
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DC Field | Value | Language |
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dc.contributor.author | Santos Barriopedro, Irene | - |
dc.contributor.author | Bosch Presegué, Laia | - |
dc.contributor.author | Marazuela Duque, Anna | - |
dc.contributor.author | Torre Gómez, Carolina de la | - |
dc.contributor.author | Colomer, Carlota | - |
dc.contributor.author | Vàzquez Prat, Berta N. | - |
dc.contributor.author | Fuhrmann, Thomas | - |
dc.contributor.author | Martínez-Pastor, Bárbara | - |
dc.contributor.author | Lu, Wenfu | - |
dc.contributor.author | Braun, Thomas | - |
dc.contributor.author | Bober, Eva | - |
dc.contributor.author | Jenuwein, Thomas | - |
dc.contributor.author | Serrano, Lourdes | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Cheng, Zhenbang | - |
dc.contributor.author | Barceló-Batllori, Sílvia | - |
dc.contributor.author | Mostoslavsky, Raúl | - |
dc.contributor.author | Espinosa, Lluís | - |
dc.contributor.author | Vaquero García, Alejandro | - |
dc.date.accessioned | 2018-03-21T10:31:07Z | - |
dc.date.available | 2018-03-21T10:31:07Z | - |
dc.date.issued | 2018-01-09 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/120949 | - |
dc.description.abstract | Sirtuins are NAD+-dependent deacetylases that facilitate cellular stress response. They include SirT6, which protects genome stability and regulates metabolic homeostasis through gene silencing, and whose loss induces an accelerated aging phenotype directly linked to hyperactivation of the NF-κB pathway. Here we show that SirT6 binds to the H3K9me3-specific histone methyltransferase Suv39h1 and induces monoubiquitination of conserved cysteines in the PRE-SET domain of Suv39h1. Following activation of NF-κB signaling Suv39h1 is released from the IκBα locus, subsequently repressing the NF-κB pathway. We propose that SirT6 attenuates the NF-κB pathway through IκBα upregulation via cysteine monoubiquitination and chromatin eviction of Suv39h1. We suggest a mechanism based on SirT6-mediated enhancement of a negative feedback loop that restricts the NF-κB pathway. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-017-02586-x | - |
dc.relation.ispartof | Nature Communications, 2018, vol. 9, num. 1, p. 101 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-017-02586-x | - |
dc.rights | cc-by (c) Santos Barriopedro, Irene et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Cromatina | - |
dc.subject.classification | Epigenètica | - |
dc.subject.classification | Histones | - |
dc.subject.other | Chromatin | - |
dc.subject.other | Epigenetics | - |
dc.subject.other | Histones | - |
dc.title | SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 677075 | - |
dc.date.updated | 2018-03-21T10:31:07Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29317652 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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677075.pdf | 2.67 MB | Adobe PDF | View/Open |
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