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http://hdl.handle.net/2445/121044
Title: | Auditory target and novelty processing in patients with unilateral hippocampal sclerosis: A current-source density study |
Author: | Vilà-Balló, Adrià François, Clément Cucurell, David Miró, Júlia Falip, Mercè Juncadella i Puig, Montserrat Rodríguez Fornells, Antoni |
Keywords: | Hipocamp (Cervell) Percepció auditiva Cognició Atenció Hippocampus (Brain) Auditory perception Cognition Attention |
Issue Date: | 9-May-2017 |
Publisher: | Nature Publishing Group |
Abstract: | The capacity to respond to novel events is crucial for adapting to the constantly changing environment. Here, we recorded 29-channel Event Related Brain Potentials (ERPs) during an active auditory novelty oddball paradigm and used for the first time Current Source Density-transformed Event Related Brain Potentials and associated time-frequency spectra to study target and novelty processing in a group of epileptic patients with unilateral damage of the hippocampus (N = 18) and in healthy matched control participants (N = 18). Importantly, we used Voxel-Based Morphometry to ensure that our group of patients had a focal unilateral damage restricted to the hippocampus and especially its medial part. We found a clear deficit for target processing at the behavioral level. In addition, compared to controls, our group of patients presented (i) a reduction of theta event-related synchronization (ERS) for targets and (ii) a reduction and delayed P3a source accompanied by reduced theta and low-beta ERS and alpha event-related synchronization (ERD) for novel stimuli. These results suggest that the integrity of the hippocampus might be crucial for the functioning of the complex cortico-subcortical network involved in the detection of novel and target stimuli. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-01531-8 |
It is part of: | Scientific Reports, 2017, num. 7, p. 1612 |
URI: | http://hdl.handle.net/2445/121044 |
Related resource: | https://doi.org/10.1038/s41598-017-01531-8 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) |
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