Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/121067
Title: | Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. |
Author: | Albuixech Crespo, Beatriz López-Blanch, L. Burguera Hernández, Demian Maeso, Ignacio Sánchez-Arrones, L. Moreno-Bravo, J. A. Somorjai, Ildikó M. L. Pascual Anaya, Juan Puelles, E. Bovolenta, P. Garcia Fernández, Jordi Puelles, L. Irimia Martínez, Manuel Ferran, J. L. |
Keywords: | Tub neural Expressió gènica Biologia molecular Cervell Neural tube Gene expression Molecular biology Brain |
Issue Date: | 19-Apr-2017 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | All vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pbio.2001573 |
It is part of: | PLoS Biology, 2017, vol. 15, num. 4, p. e2001573 |
URI: | http://hdl.handle.net/2445/121067 |
Related resource: | https://doi.org/10.1371/journal.pbio.2001573 |
ISSN: | 1544-9173 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
679194.pdf | 11.85 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License