Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/121082
Title: Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
Author: Klein, Alison P.
Wolpin, Brian M.
Risch, Harvey A.
Stolzenberg-Solomon, Rachael Z.
Mocci, Evelina
Zhang, Mingfeng
Canzian, Federico
Childs, Erica J.
Hoskins, Jason W.
Jermusyk, Ashley
Chen, Fei
Peters, Ulrike
Shu, Xiao Ou
Talar-Wojnarowska, Renata
Pezzilli, Raffaele
Porta, Miquel
Rothman, Nathaniel
Scelo, Ghislaine
Sesso, Howard D.
Sund, Malin
Silverman, Debra T.
Wentzensen, Nicolas
Smith, Jill P.
Tavano, Francesca
Thornquist, Mark D.
Arslan, Alan A.
Tobias, Geoffrey S.
Eeden, Stephen K. van den
Vashist, Yogesh
Chanock, Stephen J.
Visvanathan, Kala
Vodicka, Pavel
Zeleniuch-Jacquotte, Anne
Wactawski-Wende, Jean
Wang, Zhaoming
Amundadottir, Laufey T
White, Emily
Yu, Herbert
Yu, Kai
Zheng, Wei
Kraft, Peter
Li, Donghui
Obazee, Ofure
Andreotti, Gabriella
Brennan, Paul
Petersen, Gloria M.
Babic, Ana
Bamlet, William R.
Campa, Daniele
Beane Freeman, Laura
Berndt, Sonja I.
Blackford, Amanda
Chung, Charles C.
Borges, Michael
Borgida, Ayelet
Duell, Eric J.
Bracci, Paige M.
Albanes, Demetrius
Brais, Lauren
Brenner, Hermann
Bueno de Mesquita, H. Bas
Buring, Julie
Capurso, Gabriele
Cavestro, Giulia Martina
Chaffee, Kari G.
Dijk, Frederike
Cleary, Sean
Goggins, Michael
Cotterchio, Michelle
Zhong, Jun
Foretova, Lenka
Haiman, Christopher
Fuchs, Charles
Funel, Niccola
Gallinger, Steven
Gaziano, J. Michael M.
Herman, Joseph
Gazouli, Maria
Hartge, Patricia
Giles, Graham G.
Giovannucci, Edward
Hoover, Robert
Goodman, Gary E.
Goodman, Phyllis J
Hackert, Thilo
Hung, Rayjean J.
Hasan, Manal
Hegyi, Peter
Helzlsouer, Kathy J.
Holcatova, Ivana
Kupcinskas, Juozas
Holly, Elizabeth A.
Jacobs, Eric J.
Jamroziak, Krzysztof
Lawlor, Rita T.
Janout, Vladimir
Kaaks, Rudolf
Khaw, Kay-Tee
Klein, Eric A.
Mohelníková Duchoňová, Beatrice
Kogevinas, Manolis
Lee, I. Min
Kooperberg, Charles
Milne, Roger L.
Kulke, Matthew H.
Kurtz, Robert J.
Laheru, Daniel
Landi, Stefano
Mambrini, Andrea
LeMarchand, Loic
Lu, Lingeng
Malats, Núria
Mannisto, Satu
Real, Francisco X.
Neale, Rachel E.
Neoptolemos, John P.
Oberg, Ann L.
Severi, Gianluca
Olson, Sara H.
Orlow, Irene
Pasquali, Claudio
Patel, Alpa V.
Soucek, Pavel
Keywords: Càncer
Càncer de pàncrees
Cancer
Pancreas cancer
Issue Date: 2018
Publisher: Macmillan Publishers
Abstract: In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10−8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10−14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10−10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10−8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10−8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1038/s41467-018-02942-5
It is part of: Nature Communications, 2018, vol. 9, num. 1, p. 556
URI: http://hdl.handle.net/2445/121082
Related resource: http://dx.doi.org/10.1038/s41467-018-02942-5
ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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