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http://hdl.handle.net/2445/121109
Title: | Gut epithelial barrier markers in patients with obstructive sleep apnea |
Author: | Barceló, Antonia Esquinas López, Cristina Robles, Juan Piérola, Javier Peña, Mónica de la Aguilar, Irene Morell-Garcia, Daniel Alonso, Alberto Toledo Pons, Nuria Sánchez de la Torre, Manuel Barbé, Ferran |
Keywords: | Proteïnes portadores Fixació de proteïnes Síndrome metabòlica Absorció intestinal Síndromes d'apnea del son Obesitat Carrier proteins Protein binding Metabolic syndrome Intestinal absorption Sleep apnea syndromes Obesity |
Issue Date: | 1-Oct-2016 |
Publisher: | Elsevier B.V. |
Abstract: | Background: obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: the results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.sleep.2016.01.019 |
It is part of: | Sleep Medicine, 2016, vol. 26, p. 12-15 |
URI: | http://hdl.handle.net/2445/121109 |
Related resource: | https://doi.org/10.1016/j.sleep.2016.01.019 |
ISSN: | 1389-9457 |
Appears in Collections: | Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) |
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