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Title: Blood pressure values and depression in hypertensive individuals at high cardiovascular risk
Author: Mejía-Lancheros, Cília
Estruch Riba, Ramon
Martínez-González, Miguel Ángel, 1957-
Salas Salvadó, Jordi
Corella Piquer, Dolores
Gómez Gracia, Enrique
Fiol Sala, Miguel
Santos, José Manuel
Fitó Colomer, Montserrat
Arós, Fernando
Serra Majem, Lluís
Pintó Sala, Xavier
Basora, Josep
Sorlí, José V.
Muñoz, Miguel Ángel
Keywords: Hipertensió
Depressió psíquica
Malalties cardiovasculars
Pressió sanguínia
Assaigs clínics
Mental depression
Cardiovascular diseases
Blood pressure
Clinical trials
Issue Date: 26-Aug-2014
Publisher: BioMed Central
Abstract: BACKGROUND: Hypertension and depression are both important risk factors for cardiovascular diseases. Nevertheless, the association of blood pressure on and depression has not been completely established. This study aims to analyze whether depression may influence the control of blood pressure in hypertensive individuals at high cardiovascular risk. METHODS: Cross-sectional study, embedded within the PREDIMED clinical trial, of 5954 hypertensive patients with high cardiovascular risk factor profiles. The relationship between blood pressure control and depression was analyzed. A multivariate analysis (logistic and log-linear regression), adjusting for potential confounders (socio-demographic factors, body mass index, lifestyle, diabetes, dyslipidemia, and antihypertensive treatment), was performed. RESULTS: Depressive patients, with and without antidepressant treatment, had better blood pressure control (OR: 1.28, CI 95%: 1.06-1.55, and OR: 1.30, CI 95%: 1.03-1.65, respectively) than non-depressive ones. Regarding blood pressure levels, systolic blood pressure values (mmHg) were found to be lower in both treated and untreated depressive patients (Log coefficient Beta: -1.59, 95% CI: -0.50 to -2.69 and Log coefficient Beta: -3.49, 95% CI: -2.10 to -4.87, respectively). CONCLUSIONS: Among hypertensive patients at high cardiovascular risk, the control of blood pressure was better in those diagnosed with depression. TRIAL REGISTRATION: Unique identifier: ISRCTN35739639.
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It is part of: BMC Cardiovascular Disorders, 2014, vol. 14, num. 109
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ISSN: 1471-2261
Appears in Collections:Articles publicats en revistes (Medicina)

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