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Title: Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project
Author: Dierssen Sotos, Trinidad
Palazuelos-Calderón, Camilo
Jiménez Moleón, José Juan
Aragonès Sanz, Núria
Altzibar, Jone M.
Castaño-Vinyals, Gemma
Martín Sánchez, Vicente
Gómez Acebo, Inés
Guevara, Marcela
Tardón, Adonina
Pérez Gómez, Beatriz
Amiano, Pilar
Moreno Aguado, Víctor
Molina de la Torre, Antonio José
Alonso-Molero, Jéssica
Moreno Iribas, Conchi
Kogevinas, Manolis
Pollán, Marina
Llorca Díaz, Javier
Keywords: Càncer de mama
Factors sexuals en les malalties
Breast cancer
Sex factors in disease
Issue Date: 12-Mar-2018
Publisher: BioMed Central
Abstract: BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.
Note: Reproducció del document publicat a:
It is part of: BMC Cancer, 2018, vol. 18, num. 280
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ISSN: 1471-2407
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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