Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/121181
Title: | Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory Biomarkers during Early and Chronic HIV Infection in Mozambican Adults |
Author: | Pastor, Lucía Urrea, Victor Carrillo, Jorge Parker, Erica Fuente Soro, Laura Jairoce, Chenjerai Mandomando, Inácio Naniche, Denise Blanco, Julià |
Keywords: | Sida Infeccions per VIH Moçambic AIDS (Disease) HIV infections Mozambique |
Issue Date: | 5-Jan-2018 |
Publisher: | Frontiers Media |
Abstract: | During primary HIV infection (PHI), there is a striking cascade response of inflammatory cytokines and many cells of the immune system show altered frequencies and signs of extensive activation. These changes have been shown to have a relevant role in predicting disease progression; however, the challenges of identifying PHI have resulted in a lack of critical information about the dynamics of early pathogenic events. We studied soluble inflammatory biomarkers and changes in T-cell subsets in individuals at PHI (n = 40), chronic HIV infection (CHI, n = 56), and HIV-uninfected (n = 58) recruited at the Manhica District Hospital in Mozambique. Plasma levels of 49 biomarkers were determined by Luminex and ELISA. T-cell immunophenotyping was performed by multicolor flow cytometry. Plasma HIV viremia, CD4, and CD8 T cell counts underwent rapid stabilization after PHI. However, several immunological parameters, including Th1-Th17 CD4 T cells and activation or exhaustion of CD8 T cells continued decreasing until more than 9 months postinfection. Importantly, no sign of immunosenescence was observed over the first year of HIV infection. Levels of IP-10, MCP-1, BAFF, sCD14, tumor necrosis factor receptor-2, and TRAIL were significantly overexpressed at the first month of infection and underwent a prompt decrease in the subsequent months while, MIG and CD27 levels began to increase 1 month after infection and remained overexpressed for almost 1 year postinfection. Early levels of soluble biomarkers were significantly associated with subsequently exhausted CD4 T-cells or with CD8 T-cell activation. Despite rapid immune control of virus replication, the stabilization of the T-cell subsets occurs months after viremia and CD4 count plateau, suggesting persistent immune dysfunction and highlighting the potential benefit of early treatment initiation that could limit immunological damage. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.3389/fimmu.2017.01925 |
It is part of: | Frontiers in Immunology, 2017, vol. 8, num. 1925 |
URI: | http://hdl.handle.net/2445/121181 |
Related resource: | http://dx.doi.org/10.3389/fimmu.2017.01925 |
ISSN: | 1664-3224 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
pastor2017_2886.pdf | 4.61 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License