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http://hdl.handle.net/2445/121196
Title: | The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax |
Author: | Cosialls Castel, Ana Mª Pomares, Helena Iglesias i Serret, Daniel Saura-Esteller, José Núñez-Vázquez, Sonia González Gironés, Diana M. Banda, Esmeralda de la Preciado Gallego, Sara Albericio Palomera, Fernando Lavilla Grífols, Rodolfo Pons i Irazazábal, Gabriel González Barca, Eva Gil i Santano, Joan |
Keywords: | Apoptosi Leucèmia limfocítica crònica Malalties cròniques Càncer Apoptosis Chronic lymphocytic leukemia Chronic diseases Cancer |
Issue Date: | Sep-2017 |
Publisher: | Ferrata Storti Foundation |
Abstract: | Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia. Fluorizoline induced apoptosis in chronic lymphocytic leukemia cells at concentrations in the low micromolar range. All primary samples were sensitive to fluorizoline irrespective of patients' clinical or genetic features, whereas normal T lymphocytes were less sensitive. Fluorizoline increased the protein levels of the pro-apoptotic B-cell lymphoma 2 family member NOXA in chronic lymphocytic leukemia cells. Furthermore, fluorizoline synergized with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax to induce apoptosis. These results suggest that targeting prohibitins could be a new therapeutic strategy for chronic lymphocytic leukemia. |
Note: | Reproducció del document publicat a: https://doi.org/10.3324/haematol.2016.162958 |
It is part of: | Haematologica, 2017, vol. 102, num. 9, p. 1587-1593 |
URI: | http://hdl.handle.net/2445/121196 |
Related resource: | https://doi.org/10.3324/haematol.2016.162958 |
ISSN: | 0390-6078 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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