Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/121403
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Campillo, Noelia | - |
dc.contributor.author | Torres, Marta | - |
dc.contributor.author | Vilaseca, Antoni | - |
dc.contributor.author | Nonaka, Paula Naomi | - |
dc.contributor.author | Gozal, David | - |
dc.contributor.author | Roca i Ferrer, Jordi | - |
dc.contributor.author | Picado Vallés, César | - |
dc.contributor.author | Montserrat Canal, José Ma. | - |
dc.contributor.author | Farré Ventura, Ramon | - |
dc.contributor.author | Navajas Navarro, Daniel | - |
dc.contributor.author | Almendros López, Isaac | - |
dc.date.accessioned | 2018-04-10T11:45:07Z | - |
dc.date.available | 2018-04-10T11:45:07Z | - |
dc.date.issued | 2017-03-16 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/121403 | - |
dc.description.abstract | An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently emerged from clinical and animal studies. In animals, intermittent hypoxia (IH) mimicking OSA promotes tumor malignancy both directly and via host immune alterations. We hypothesized that IH could potentiate cancer aggressiveness through activation of the cyclooxygenase-2 (COX-2) pathway and the concomitant increases in prostaglandin E2 (PGE2). The contribution of the COX-2 in IH-induced enhanced tumor malignancy was assessed using celecoxib as a COX-2 specific inhibitor in a murine model of OSA bearing Lewis lung carcinoma (LLC1) tumors. Exposures to IH accelerated tumor progression with a tumor associated macrophages (TAMs) shift towards a pro-tumoral M2 phenotype. Treatment with celecoxib prevented IH-induced adverse tumor outcomes by inhibiting IH-induced M2 polarization of TAMs. Furthermore, TAMs isolated from IH-exposed mice treated with celecoxib reduced the proliferation of LLC1 naïve cells, while the opposite occurred with placebo-treated IH-exposed mice. Finally, in vitro IH exposures of murine macrophages and LLC1 cells showed that both cell types increased PGE2 release in response to IH. These results suggest a crucial role for the COX-2 signaling pathway in the IH-exacerbated malignant processes, and designate macrophages and lung adenocarcinoma cells, as potential sources of PGE2. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep44693 | - |
dc.relation.ispartof | Scientific Reports, 2017, vol. 7, num. 44693 | - |
dc.relation.uri | https://doi.org/10.1038/srep44693 | - |
dc.rights | cc-by (c) Campillo, Noelia et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Síndromes d'apnea del son | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Sleep apnea syndromes | - |
dc.subject.other | Cancer | - |
dc.title | Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 672394 | - |
dc.date.updated | 2018-04-10T11:45:07Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28300223 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
672394.pdf | 1.4 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License