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http://hdl.handle.net/2445/121515
Title: | Antiparkinsonian efficacy of guanosine in rodent models of movement disorder |
Author: | Massari, Caio M. López-Cano, Marc Núñez, Fabiana Fernández Dueñas, Víctor Tasca, Carla I. Ciruela Alférez, Francisco |
Keywords: | Malaltia de Parkinson Trastorns motors Tremolor Nucleòsids Parkinson's disease Movement disorders Tremor Nucleosides |
Issue Date: | 4-Oct-2017 |
Publisher: | Frontiers Media |
Abstract: | Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson's disease (PD), its efficacy as an antiparkinsonian agent has not been fully explored in PD animal models. Accordingly, we evaluated the effectiveness of GUO in reversing motor impairments in several rodent movement disorder models, including catalepsy, tremor, and hemiparkinsonism. Our results showed that orally administered GUO antagonized reserpine-mediated catalepsy, reduced reserpine-induced tremulous jaw movements, and potentiated the number of contralateral rotations induced by L-3,4-dihydroxyphenylalanine in unilaterally 6-hydroxidopamine-lesioned rats. In addition, at 5 and 7.5 mg/kg, GUO inhibited L-DOPA-induced dyskinesia in rats chronically treated with a pro-dopaminergic agent. Overall, we describe the therapeutic potential of GUO, which may be effective not only for reversing parkinsonian motor impairments but also for reducing dyskinesia induced by treatment for PD. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fphar.2017.00700 |
It is part of: | Frontiers in Pharmacology, 2017, vol. 8, p. 700 |
URI: | http://hdl.handle.net/2445/121515 |
Related resource: | https://doi.org/10.3389/fphar.2017.00700 |
ISSN: | 1663-9812 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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