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Title: Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure.
Author: Moncunill, Gemma
Mayor Aparicio, Alfredo Gabriel
Jiménez, Alfons
Nhabomba, Augusto
Puyol, Laura
Manaca, Maria Nélia
Barrios, Diana
Cisteró, Pau
Guinovart, Caterina
Aguilar, Ruth
Bardají, Azucena
Pinazo, María Jesús
Angov, Evelina
Dutta, Sheetij
Chitnis, Chetan E.
Muñoz, José
Gascón i Brustenga, Joaquim
Dobaño, Carlota, 1969-
Keywords: Citoquines
Plasmodium falciparum
Plasmodium falciparum
Issue Date: 21-Feb-2013
Publisher: Public Library of Science (PLoS)
Abstract: Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-142 (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P≤0.0090), IL-2 (P≤0.0379) and IL-8 (P≤0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1β (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A TH1/pro-inflammatory response was the hallmark of non-immune subjects.
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It is part of: PLoS One, 2013
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (ISGlobal)

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