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http://hdl.handle.net/2445/121776
Title: | Cytokine profiling in immigrants with clinical malaria after extended periods of interrupted exposure to Plasmodium falciparum. |
Author: | Moncunill, Gemma Mayor Aparicio, Alfredo Gabriel Bardají, Azucena Puyol, Laura Nhabomba, Augusto J. Barrios, Diana Aguilar, Ruth Pinazo, Maria-Jesus Almirall, Mercè Soler, Cristina Muñoz, José Gascón i Brustenga, Joaquim Dobaño, Carlota, 1969- |
Keywords: | Citoquines Malària Immigrants Plasmodium falciparum Cytokines Malaria Immigrants Plasmodium falciparum |
Issue Date: | 14-Aug-2013 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Immunity to malaria is believed to wane with time in the absence of exposure to Plasmodium falciparum infection, but immunoepidemiological data on longevity of immunity remain controversial. We quantified serum cytokines and chemokines by suspension array technology as potential biomarkers for durability of immunity in immigrants with clinical malaria after years without parasite exposure. These were compared to serum/plasma profiles in naïve adults (travelers) and semi-immune adults under continuous exposure, with malaria, along with immigrant and traveler patients without malaria. Immigrants had higher levels of IL-2, IL-5 and IL-8 compared to semi-immune adults with malaria (P≤0.0200). Time since immigration correlated with increased IL-2 (rho=0.2738P=0.0495) and IFN-γ (rho=0.3044P=0.0282). However, immigrants did not show as high IFN-γ concentrations as travelers during a first malaria episode (P<0.0001). Immigrants and travelers with malaria had higher levels of IFN-γ, IL-6, and IL-10 (P<0.0100) than patients with other diseases, and IL-8 and IL-1β were elevated in immigrants with malaria (P<0.0500). Therefore, malaria patients had a characteristic strong pro-inflammatory/Th1 signature. Upon loss of exposure, control of pro-inflammatory responses and tolerance to P. falciparum appeared to be reduced. Understanding the mechanisms to maintain non-pathogenic effector responses is important to develop new malaria control strategies. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0073360 |
It is part of: | PLoS One, 2013 |
URI: | http://hdl.handle.net/2445/121776 |
Related resource: | https://doi.org/10.1371/journal.pone.0073360 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Medicina) |
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