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http://hdl.handle.net/2445/121811
Title: | Importance of biofilms in urinary tract infections: new therapeutic approaches |
Author: | Soto González, Sara M. |
Keywords: | Infeccions del tracte urinari Medicaments antibacterians Biofilms Resistència als medicaments Terapèutica Urinary tract infections Antibacterial agents Biofilms Drug resistance Therapeutics |
Issue Date: | 27-Mar-2014 |
Publisher: | Hindawi Publishing Corporation |
Abstract: | Bacterial biofilms play an important role in urinary tract infections (UTIs), being responsible for persistence infections causing relapses and acute prostatitis. Bacterial forming biofilm are difficult to eradicate due to the antimicrobial resistant phenotype that this structure confers being combined therapy recommended for the treatment of biofilm-associated infections. However, the presence of persistent cells showing reduced metabolism that leads to higher levels of antimicrobial resistance makes the search for new therapeutic tools necessary. Here, a review of these new therapeutic approaches is provided including catheters coated with hydrogels or antibiotics, nanoparticles, iontophoresis, biofilm enzyme inhibitors, liposomes, bacterial interference, bacteriophages, quorum sensing inhibitors, low-energy surface acoustic waves, and antiadhesion agents. In conclusion, new antimicrobial drugs that inhibit bacterial virulence and biofilm formation are needed. |
Note: | Reproducció del document publicat a: https://doi.org/10.1155/2014/543974 |
It is part of: | Advances in Biology , 2014, vol. 2014 |
URI: | http://hdl.handle.net/2445/121811 |
Related resource: | https://doi.org/10.1155/2014/543974 |
ISSN: | 2356-6582 |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
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