Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/122201
Title: Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study)
Author: García Saenz, Ariadna
Sánchez de Miguel, Alejandro
Espinosa Cardiel, Ana
Valentín, Antònia
Aragonès Sanz, Núria
Llorca Díaz, Javier
Amiano, Pilar
Martín Sánchez, Vicente
Guevara, Marcela
Capelo, Rocío
Tardón, Adonina
Peiró Pérez, Rosana
Jiménez-Moleón, José Juan
Roca Barceló, Aina
Pérez Gómez, Beatriz
Dierssen Sotos, Trinidad
Fernández Villa, Tania
Moreno Iribas, Conchi
Moreno Aguado, Víctor
García Pérez, Javier
Castaño-Vinyals, Gemma
Pollán, Marina
Aubé, Martin
Kogevinas, Manolis
Keywords: Càncer de mama
Càncer de pròstata
Breast cancer
Prostate cancer
Issue Date: Apr-2018
Publisher: National Institute of Environmental Health Sciences
Abstract: BACKGROUND: Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers. OBJECTIVES: We evaluated the association of exposure to ALAN during sleeping time with breast and prostate cancer in a population based multicase–control study (MCC-Spain), among subjects who had never worked at night. We evaluated chronotype, a characteristic that may relate to adaptation to light at night. METHODS: We enrolled 1,219 breast cancer cases, 1,385 female controls, 623 prostate cancer cases, and 879 male controls from 11 Spanish regions in 2008–2013. Indoor ALAN information was obtained through questionnaires. Outdoor ALAN was analyzed using images from the International Space Station (ISS) available for Barcelona and Madrid for 2012–2013, including data of remotely sensed upward light intensity and blue light spectrum information for each geocoded longest residence of each MCC-Spain subject. RESULTS: Among Barcelona and Madrid participants with information on both indoor and outdoor ALAN, exposure to outdoor ALAN in the blue light spectrum was associated with breast cancer [adjusted odds ratio (OR) for highest vs. lowest tertile, OR=1.47; 95% CI: 1.00, 2.17] and prostate cancer (OR=2.05; 95% CI: 1.38, 3.03). In contrast, those exposed to the highest versus lowest intensity of outdoor ALAN were more likely to be controls than cases, particularly for prostate cancer. Compared with those who reported sleeping in total darkness, men who slept in “quite illuminated” bedrooms had a higher risk of prostate cancer (OR=2.79; 95% CI: 1.55, 5.04), whereas women had a slightly lower risk of breast cancer (OR=0.77; 95% CI: 0.39, 1.51). CONCLUSION: Both prostate and breast cancer were associated with high estimated exposure to outdoor ALAN in the blue-enriched light spectrum.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1289/EHP1837
It is part of: Environmental Health Perspectives, 2018, vol. 126, num. 4, p. 047011-1-047011-11
URI: http://hdl.handle.net/2445/122201
Related resource: http://dx.doi.org/10.1289/EHP1837
ISSN: 0091-6765
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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