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Title: Maternal Smoking during Pregnancy and Early Childhood and Development of Asthma and Rhinoconjunctivitis - a MeDALL Project
Author: Thacher, Jesse D.
Gehring, Ulrike
Gruzieva, Olena
Standl, Marie
Pershagen, Göran
Bauer, Carl-Peter
Berdel, Dietrich
Keller, Theresa
Koletzko, Sibylle
Koppelman, Gerard H.
Kull, Inger
Lau, Susanne
Lehmann, Irina
Maier, Dieter
Schikowski, Tamara
Wahn, Ulrich
Wijga, Alet H.
Heinrich, Joachim
Bousquet, Jean
Antó i Boqué, Josep Maria
Berg, Andrea von
Melén, Erik
Smit, Henriette A.
Keil, Thomas
Bergstrom, Anna
Keywords: Embarassades
Hàbit de fumar en l'embaràs
Pregnant women
Pregnant women Tobacco use
Issue Date: Apr-2018
Publisher: National Institute of Environmental Health Sciences
Abstract: BACKGROUND: The role of tobacco smoke exposure in the development and persistence of asthma and rhinoconjunctivitis through childhood into adolescence is unclear. OBJECTIVES: We assessed the associations of parental smoking from fetal life through adolescence with asthma and rhinoconjunctivitis during childhood and adolescence. METHODS: We analyzed data for 10,860 participants of five European birth cohort studies from the Mechanisms of the Development of Allergy (MeDALL) consortium. Parental smoking habits and health outcomes (early transient, persistent, and adolescent-onset asthma and rhinoconjunctivitis) were based on questionnaires covering the period from pregnancy to 14-16 y of age. Data were combined and analyzed using a one-stage and two-stage individual participant data meta-analysis. RESULTS: Overall, any maternal smoking during pregnancy tended to be associated with an increased odds of prevalent asthma [adjusted odds ratio (aOR)=1.19 (95% CI: 0.98, 1.43)], but not prevalent rhinoconjunctivitis [aOR=1.05 (95% CI: 0.90, 1.22)], during childhood and adolescence. In analyses with phenotypes related to age of onset and persistence of disease, any maternal smoking during pregnancy was associated with early transient asthma [aOR=1.79 (95% CI: 1.14, 2.83)]. Maternal smoking of >/=10 cigarettes/day during pregnancy was associated with persistent asthma [aOR=1.66 (95% CI: 1.29, 2.15)] and persistent rhinoconjunctivitis [aOR=1.55 (95% CI, 1.09, 2.20)]. Tobacco smoke exposure during fetal life, infancy, childhood, and adolescence was not associated with adolescent-onset asthma or rhinoconjunctivitis. CONCLUSIONS: Findings from this combined analysis of five European birth cohorts strengthen evidence linking early exposure to tobacco smoke with asthma during childhood and adolescence. Children with high early-life exposure were more likely than unexposed children to have early transient and persistent asthma and persistent rhinoconjunctivitis.
Note: Reproducció del document publicat a:
It is part of: Environmental Health Perspectives, 2018, vol. 126, num. 4, p. 047005-1-047005-13
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ISSN: 0091-6765
Appears in Collections:Articles publicats en revistes (ISGlobal)

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