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http://hdl.handle.net/2445/122379
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DC Field | Value | Language |
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dc.contributor.author | Navarro Brugal, Gemma | - |
dc.contributor.author | Cordomí, Arnau | - |
dc.contributor.author | Casadó Anguera, Verònica | - |
dc.contributor.author | Moreno Guillén, Estefanía | - |
dc.contributor.author | Cai, Ning-Sheng | - |
dc.contributor.author | Cortes, Antoni | - |
dc.contributor.author | Canela Campos, Enric I. | - |
dc.contributor.author | Dessauer, Carmen W. | - |
dc.contributor.author | Casadó, Vicent | - |
dc.contributor.author | Pardo, Leonardo | - |
dc.contributor.author | Lluís i Biset, Carme | - |
dc.contributor.author | Ferré, Sergi | - |
dc.date.accessioned | 2018-05-15T14:24:30Z | - |
dc.date.available | 2018-05-15T14:24:30Z | - |
dc.date.issued | 2018-03-28 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/122379 | - |
dc.description.abstract | G protein-coupled receptors (GPCRs), G proteins and adenylyl cyclase (AC) comprise one of the most studied transmembrane cell signaling pathways. However, it is unknown whether the ligand-dependent interactions between these signaling molecules are based on random collisions or the rearrangement of pre-coupled elements in a macromolecular complex. Furthermore, it remains controversial whether a GPCR homodimer coupled to a single heterotrimeric G protein constitutes a common functional unit. Using a peptide-based approach, we here report evidence for the existence of functional pre-coupled complexes of heteromers of adenosine A2A receptor and dopamine D2 receptor homodimers coupled to their cognate Gs and Gi proteins and to subtype 5 AC. We also demonstrate that this macromolecular complex provides the necessary frame for the canonical Gs-Gi interactions at the AC level, sustaining the ability of a Gi-coupled GPCR to counteract AC activation mediated by a Gs-coupled GPCR. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-03522-3 | - |
dc.relation.ispartof | Nature Communications, 2018, vol. 9, num. 1, pp.1242 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-018-03522-3 | - |
dc.rights | cc-by (c) Navarro Brugal, Gemma et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Adenosina | - |
dc.subject.classification | Receptors cel·lulars | - |
dc.subject.other | Adenosine | - |
dc.subject.other | Cell receptors | - |
dc.title | Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 680316 | - |
dc.date.updated | 2018-05-15T14:24:30Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29593213 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
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680316.pdf | 2.56 MB | Adobe PDF | View/Open |
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