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Title: Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
Author: Moreno Guillén, Estefanía
Andradas, Clara
Medrano, Mireia
Caffarel, María M.
Pérez-Gómez, Eduardo
Blasco-Benito, Sandra
Gómez-Cañas, María
Pazos, M. Ruth
Irving, Andrew J.
Lluís i Biset, Carme
Canela Campos, Enric I.
Fernández-Ruiz, Javier
Guzmán, Manuel
McCormick, Peter J.
Sánchez, Cristina
Keywords: Transducció de senyal cel·lular
Cellular signal transduction
Issue Date: 8-Aug-2014
Publisher: American Society for Biochemistry and Molecular Biology
Abstract: The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.
Note: Reproducció del document publicat a:
It is part of: Journal of Biological Chemistry, 2014, vol. 289, num. 32, p. 21960-21972
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ISSN: 0021-9258
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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