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Title: IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy
Author: Mayor Aparicio, Alfredo Gabriel
Dobaño, Carlota, 1969-
Nhabomba, Augusto
Guinovart, Caterina
Jiménez, Alfons
Manaca, Maria Nelia
Aguilar, Ruth
Barbosa, Arnoldo
Rodriguez, Mauricio H.
Cisteró, Pau
Quimice, Lazaro M.
Menéndez, Clara
Aponte, John J.
Ordi i Majà, Jaume
Chitnis, Chetan E.
Alonso, Pedro
Keywords: Plasmodium falciparum
Plasmodium falciparum
Issue Date: 10-May-2018
Publisher: BioMed Central
Abstract: BACKGROUND: Difficulties to disentangle the protective versus exposure role of anti-malarial antibodies hamper the identification of clinically-relevant immune targets. Here, factors affecting maternal IgG and IgMs against Plasmodium falciparum antigens, as well as their relationship with parasite infection and clinical outcomes, were assessed in mothers and their children. Antibody responses among 207 Mozambican pregnant women at delivery against MSP119, EBA175, AMA1, DBLalpha and parasite lysate (3D7, R29 and E8B parasite lines), as well as the surface of infected erythrocytes, were assessed by enzyme-linked immunosorbent assay and flow cytometry. The relationship between antibody levels, maternal infection and clinical outcomes was assessed by multivariate regression analysis. RESULTS: Placental infection was associated with an increase in maternal levels of IgGs and IgMs against a broad range of parasite antigens. The multivariate analysis including IgGs and IgMs showed that the newborn weight increased with increasing IgG levels against a parasite lysate, whereas the opposite association was found with IgMs. IgGs are markers of protection against poor pregnancy outcomes and IgMs of parasite exposure. CONCLUSIONS: Adjusting the analysis for the simultaneous effect of IgMs and IgGs can contribute to account for heterogeneous exposure to P. falciparum when assessing immune responses effective against malaria in pregnancy.
Note: Reproducció del document publicat a:
It is part of: Malaria Journal, 2018, vol. 17, num. 182
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ISSN: 1475-2875
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Fonaments Clínics)

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