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Title: | Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy |
Author: | Vinaixa, Maria Rodríguez, Miguel Angel Samino Gené, Sara Díaz, Marta Ribas i Beltran, Antoni, 1946- Mallol, Roger Bladé, Cinta Ibáñez Toda, Lourdes Correig, Xavier Yanes, Oscar |
Keywords: | Metabòlits Malalties de l'ovari Metabolites Ovary diseases |
Issue Date: | 16-Dec-2011 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Polycystic ovary syndrome (PCOS) is a variable disorder characterized by a broad spectrum of anomalies, including hyperandrogenemia, insulin resistance, dyslipidemia, body adiposity, low-grade inflammation and increased cardiovascular disease risks. Recently, a new polytherapy consisting of low-dose flutamide, metformin and pioglitazone in combination with an estro-progestagen resulted in the regulation of endocrine clinical markers in young and non-obese PCOS women. However, the metabolic processes involved in this phenotypic amelioration remain unidentified. In this work, we used NMR and MS-based untargeted metabolomics to study serum samples of young non-obese PCOS women prior to and at the end of a 30 months polytherapy receiving low-dose flutamide, metformin and pioglitazone in combination with an estro-progestagen. Our results reveal that the treatment decreased the levels of oxidized LDL particles in serum, as well as downstream metabolic oxidation products of LDL particles such as 9- and 13-HODE, azelaic acid and glutaric acid. In contrast, the radiuses of small dense LDL and large HDL particles were substantially increased after the treatment. Clinical and endocrine-metabolic markers were also monitored, showing that the level of HDL cholesterol was increased after the treatment, whereas the level of androgens and the carotid intima-media thickness were reduced. Significantly, the abundance of azelaic acid and the carotid intima-media thickness resulted in a high degree of correlation. Altogether, our results reveal that this new polytherapy markedly reverts the oxidant status of untreated PCOS women, and potentially improves the pro-atherosclerosis condition in these patients. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0029052 |
It is part of: | PLoS One, 2011, vol. 6, num. 12, p. 1e29052 |
URI: | http://hdl.handle.net/2445/122858 |
Related resource: | https://doi.org/10.1371/journal.pone.0029052 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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