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http://hdl.handle.net/2445/123208
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DC Field | Value | Language |
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dc.contributor.author | Mancera, Pilar | - |
dc.contributor.author | Wappenhans, Blanca | - |
dc.contributor.author | Cordobilla, Begoña | - |
dc.contributor.author | Virgili, Noemi | - |
dc.contributor.author | Pugliese, Marco | - |
dc.contributor.author | Rueda, Fèlix, 1951- | - |
dc.contributor.author | Espinosa Parrilla, Juan Francisco | - |
dc.contributor.author | Domingo, Pere (Domingo Pedrol) | - |
dc.date.accessioned | 2018-06-22T11:02:57Z | - |
dc.date.available | 2018-06-22T11:02:57Z | - |
dc.date.issued | 2017-06-30 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123208 | - |
dc.description.abstract | Many neurodegenerative diseases are associated, at least in part, to an inflammatory process in which microglia plays a major role. The effect of the triglyceride form of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (TG-DHA) was assayed in vitro and in vivo to assess the protective and anti-inflammatory activity of this compound. In the in vitro study, BV-2 microglia cells were previously treated with TG-DHA and then activated with Lipopolysaccharide (LPS) and Interferon-gamma (IFN-γ). TG-DHA treatment protected BV-2 microglia cells from oxidative stress toxicity attenuating NO production and suppressing the induction of inflammatory cytokines. When compared with DHA in the ethyl-ester form, a significant difference in the ability to inhibit NO production in favor of TG-DHA was observed. TG-DHA inhibited significantly splenocyte proliferation but isolated CD4+ lymphocyte proliferation was unaffected. In a mice model of autoimmune encephalomyelitis (EAE), 250 mg/kg/day oral TG-DHA treatment was associated with a significant amelioration of the course and severity of the disease as compared to untreated animals. TG-DHA-treated EAE mice showed a better weight profile, which is a symptom related to a better course of encephalomyelitis. TG-DHA may be a promising therapeutic agent in neuroinflammatory processes and merit to be more extensively studied in human neurodegenerative disorders. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/nu9070681 | - |
dc.relation.ispartof | Nutrients, 2017, vol. 9(7), num. 681 | - |
dc.relation.uri | https://doi.org/10.3390/nu9070681 | - |
dc.rights | cc-by (c) Mancera, Pilar et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Micròglia | - |
dc.subject.classification | Estrès oxidatiu | - |
dc.subject.other | Microglia | - |
dc.subject.other | Oxidative stress | - |
dc.title | Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 675426 | - |
dc.date.updated | 2018-06-22T11:02:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28665331 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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675426.pdf | 2.58 MB | Adobe PDF | View/Open |
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