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|Title:||Medical imaging for the tracking of micromotors|
Martínez Villacorta, Angel M.
Gómez Vallejo, Vanessa
Sánchez Ordóñez, Samuel
Robòtica en medicina
Robotics in medicine
|Publisher:||American Chemical Society|
|Abstract:||Micro/nanomotors are useful tools for several biomedical applications, including targeted drug delivery and minimally invasive microsurgeries. However, major challenges such as in vivo imaging need to be addressed before they can be safely applied on a living body. Here, we show that positron emission tomography (PET), a molecular imaging technique widely used in medical imaging, can also be used to track a large population of tubular Au/PEDOT/Pt micromotors. Chemisorption of an iodine isotope onto the micromotorâ€™s Au surface rendered them detectable by PET, and we could track their movements in a tubular phantom over time frames of up to 15 min. In a second set of experiments, micromotors and the bubbles released during self-propulsion were optically tracked by video imaging and bright-field microscopy. The results from direct optical tracking agreed with those from PET tracking, demonstrating that PET is a suitable technique for the imaging of large populations of active micromotors in opaque environments, thus opening opportunities for the use of this mature imaging technology for the in vivo localization of artificial swimmers.|
|Note:||Versió postprint del document publicat a: http://dx.doi.org/10.1021/acsnano.7b07220|
|It is part of:||ACS Nano, 2018, vol. 12, num. 2, p. 1120-1227|
|Appears in Collections:||Publicacions de projectes de recerca finançats per la UE|
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
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