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http://hdl.handle.net/2445/123475
Title: | Enzyme-powered nanobots enhance anticancer drug delivery |
Author: | Hortelão, Ana C. Patiño, Tania Pérez Jiménez, Ariadna Blanco, Ángel Sánchez Ordóñez, Samuel |
Keywords: | Nanotecnologia Medicaments antineoplàstics Nanotechnology Antineoplastic agents |
Issue Date: | 27-Nov-2017 |
Publisher: | Wiley |
Abstract: | The use of enzyme catalysis to power micro- and nanomotors exploiting biocompatible fuels has opened new ventures for biomedical applications such as the active transport and delivery of specific drugs to the site of interest. Here, urease-powered nanomotors (nanobots) for doxorubicin (Dox) anticancer drug loading, release, and efficient delivery to cells are presented. These mesoporous silica-based core-shell nanobots are able to self-propel in ionic media, as confirmed by optical tracking and dynamic light scattering analysis. A four-fold increase in drug release is achieved by nanobots after 6 h compared to their passive counterparts. Furthermore, the use of Dox-loaded nanobots presents an enhanced anticancer efficiency toward HeLa cells, which arises from a synergistic effect of the enhanced drug release and the ammonia produced at high concentrations of urea substrate. A higher content of Dox inside HeLa cells is detected after 1, 4, 6, and 24 h incubation with active nanobots compared to passive Dox-loaded nanoparticles. The improvement in drug delivery efficiency achieved by enzyme-powered nanobots may hold potential toward their use in future biomedical applications such as the substrate-triggered release of drugs in target locations. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1002/adfm.201705086 |
It is part of: | Advanced Functional Materials, 2018, vol. 28, p. 1705086 |
URI: | http://hdl.handle.net/2445/123475 |
Related resource: | http://dx.doi.org/10.1002/adfm.201705086 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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L21_2018_Advanced Functional Materials_28_1705086_OA.pdf | 2.11 MB | Adobe PDF | View/Open |
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