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Title: Enzyme-powered hollow mesoporous Janus nanomotors
Author: Ma, Xing
Jannasch, Anita
Albrecth, Urban-Raphael
Hahn, Kersten
Miguel López, Albert
Schäffer, Erik
Sánchez Ordóñez, Samuel
Keywords: Sílice
Issue Date: 14-Oct-2015
Publisher: American Chemical Society
Abstract: The development of synthetic nanomotors for technological applications in particular for life science and nanomedicine is a key focus of current basic research. However, it has been challenging to make active nanosystems based on biocompatible materials consuming nontoxic fuels for providing self-propulsion. Here, we fabricate self-propelled Janus nanomotors based on hollow mesoporous silica nanoparticles (HMSNPs), which are powered by biocatalytic reactions of three different enzymes: catalase, urease, and glucose oxidase (GOx). The active motion is characterized by a mean-square displacement (MSD) analysis of optical video recordings and confirmed by dynamic light scattering (DLS) measurements. We found that the apparent diffusion coefficient was enhanced by up to 83%. In addition, using optical tweezers, we directly measured a holding force of 64 ± 16 fN, which was necessary to counteract the effective self-propulsion force generated by a single nanomotor. The successful demonstration of biocompatible enzyme-powered active nanomotors using biologically benign fuels has a great potential for future biomedical applications.
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It is part of: Nano Letters, 2015, vol. 15, num. 10, p. 7043-7050
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Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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