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http://hdl.handle.net/2445/123493
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DC Field | Value | Language |
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dc.contributor.author | Stanton, Morgan M. | - |
dc.contributor.author | Park, Byung-Wook | - |
dc.contributor.author | Vilela, Diana | - |
dc.contributor.author | Bente, Klaas | - |
dc.contributor.author | Faivre, Damien | - |
dc.contributor.author | Sitti, Metin | - |
dc.contributor.author | Sánchez Ordóñez, Samuel | - |
dc.date.accessioned | 2018-07-11T14:00:54Z | - |
dc.date.available | 2018-07-11T14:00:54Z | - |
dc.date.issued | 2017-09-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/123493 | - |
dc.description.abstract | Biofilm colonies are typically resistant to general antibiotic treatment and require targeted methods for their removal. One of these methods include the use of nanoparticles as carriers for antibiotic delivery, where they randomly circulate in fluid until they make contact with the infected areas. However, the required proximity of the particles to the biofilm results in only moderate efficacy. We demonstrate here that the non-pathogenic magnetotactic bacteria, Magnetosopirrillum gryphiswalense (MSR-1), can be integrated with drug-loaded mesoporous silica microtubes (MSMs) to build controllable microswimmers (biohybrids) capable of antibiotic delivery to target an infectious biofilm. Applying external magnetic guidance capability and swimming power of the MSR-1 cells, the biohybrids are directed to and forcefully pushed into matured Escherichia coli (E. coli) biofilms. Release of the antibiotic, ciprofloxacin (CFX), is triggered by the acidic microenvironment of the biofilm ensuring an efficient drug delivery system. The results reveal the capabilities of a non-pathogenic bacteria species to target and dismantle harmful biofilms, indicating biohybrid systems have great potential for anti-biofilm applications. | ca |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1021/acsnano.7b04128 | - |
dc.relation.ispartof | ACS Nano, 2017, vol. 11, num. 10, p. 9968-9978 | - |
dc.relation.uri | http://dx.doi.org/10.1021/acsnano.7b04128 | - |
dc.rights | (c) American Chemical Society, 2017 | - |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Bacteris | - |
dc.subject.classification | Escheríchia coli | - |
dc.subject.classification | Biofilms | - |
dc.subject.other | Bacteria | - |
dc.subject.other | Escherichia coli | - |
dc.title | Magnetotactic bacteria powered biohybrids target E. coli biofilms | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/311529/EU//LT-NRBS | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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L21_2017_ACS Nano_11_9968.pdf | 9.29 MB | Adobe PDF | View/Open |
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