Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/123497
Title: Unraveling the Role of Angiogenesis in Cancer Ecosystems
Author: Zuazo Gaztelu, Iratxe
Casanovas, Oriol
Keywords: Angiogènesi
Càncer
Neovascularization
Cancer
Issue Date: 2-Jul-2018
Publisher: Frontiers Media
Abstract: Activation of the tumor and stromal cell-driven angiogenic program is one of the first requirements in the tumor ecosystem for growth and dissemination. The understanding of the dynamic angiogenic tumor ecosystem has rapidly evolved over the last decades. Beginning with the canonical sprouting angiogenesis, followed by vasculogenesis and intussusception, and finishing with vasculogenic mimicry, the need for different neovascularization mechanisms is further explored. In addition, an overview of the orchestration of angiogenesis within the tumor ecosystem cellular and molecular components is provided. Clinical evidence has demonstrated the effectiveness of traditional vessel-directed antiangiogenics, stressing on the important role of angiogenesis in tumor establishment, dissemination, and growth. Particular focus is placed on the interaction between tumor cells and their surrounding ecosystem, which is now regarded as a promising target for the development of new antiangiogenics.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3389/fonc.2018.00248
It is part of: Frontiers in Oncology, 2018, vol. 8, num. 248
Related resource: http://dx.doi.org/10.3389/fonc.2018.00248
URI: http://hdl.handle.net/2445/123497
ISSN: 2234-943X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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