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Title: Daily allergic multimorbidity in rhinitis using mobile technology: a novel concept of the MASK study
Author: Bousquet, Jean
Devillier, P.
Antó i Boqué, Josep Maria
Bewick, M.
Haahtela, T.
Arnavielhe, S.
Bedbrook, A.
Murray, R.
van Eerd, M.
Fonseca, J. A.
Morais‑Almeida, M.
Todo Bom, A.
Menditto, E.
Passalacqua, Giovanni
Stellato, C.
Triggiani, M.
Ventura, M. T.
Vezzani, G.
Annesi-Maesano, Isabella
Bourret, R.
Bosse, I.
Caimmi, D.
Cartier, C.
Demoly, Pascal
Just, J.
Portejoie, F.
Siroux, Valérie
Viart, F.
Bergmann, K. C.
Keil, Thomas
Klimek, Ludger
Mösges, Ralph
Pfaar, Oliver
Shamai, S.
Zuberbier, T.
Mullol i Miret, Joaquim
Valero, Antonio
Spranger, O.
Tomazic, Peter‑Valentin
Kowalski, Marek L.
Kuna, P.
Kupczyk, M.
Raciborski, F.
Samolinski, B.
Toppila‑Salmi, Sanna
Valovirta, E.
Cruz, A. A.
Sarquis Serpa, F.
da Silva, J.
Stelmach, R.
Larenas‑Linnemann, D. E.
Rodríguez González, M.
Burguete Cabañas, M. T.
Kvedariene, V.
Valiulis, A.
Chavannes, N. H.
Fokkens, W. J.
Ryan, D.
Sheikh, A.
Bachert, C.
Hellings, P. W.
VandenPlas, O.
Ballardini, N.
Kull, Inger
Melén, Erik
Wickman, Magnus
Bindslev Jensen, C.
Eller, E.
Bosnic-Anticevich, S.
O'Hehir, R. E.
Agache, Ioana
Bieber, T.
Casale, T.
Gemicioğlu, B.
Ivancevich, J. C.
Vries, G. De
Sorensen, M.
Yorgancioglu, A.
Laune, D.
Westman, M.
MACVIA working group
Keywords: Morbiditat
Malalties de l'aparell respiratori
Respiratory organs diseases
Issue Date: 22-Mar-2018
Publisher: Wiley
Abstract: Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary, Methods: We undertook a one year prospective observational study in which 4,210 users and 32,585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e. global evaluation, nose, eyes, asthma and work). VAS levels <20/100 were categorized as “Low” burden and VAS levels ≥50/100 as “High” burden. Results: VAS global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on “Low” and “High” VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High - Asthma Low pattern. There were 1.7% days with a Rhinitis High – Asthma High – Conjunctivitis Low pattern. A novel Rhinitis High - Asthma High - Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.
Note: Versió postprint del document publicat a:
It is part of: Allergy, 2018
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Appears in Collections:Articles publicats en revistes (ISGlobal)

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