Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/123544
Title: Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures
Author: Simó, Marta
Gurtubay-Antolin, Ane
Vaquero, Lucía
Bruna, Jordi
Rodríguez Fornells, Antoni
Keywords: Càncer de pulmó
Quimioteràpia
Lung cancer
Chemotherapy
Issue Date: 28-Dec-2017
Publisher: Elsevier
Abstract: No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C+) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C-) prior to chemotherapy and a healthy control group (HC). Seventeen SCLC (C+) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender-and education-matched NSCLC (C-) and eighteen HC. Between 20 and 30% of patients in both lung cancer groups (C+ and C-) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC. Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population.
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.nicl.2017.12.032
It is part of: Neuroimage: Clinical, vol. 18, p. 11
Related resource: https://doi.org/10.1016/j.nicl.2017.12.032
URI: http://hdl.handle.net/2445/123544
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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