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http://hdl.handle.net/2445/123919
Title: | Hpv-relatedness Definitions For Classifying Hpv-related Oropharyngeal Cancer Patient Do Impact On Tnm Classification And Patients' Survival |
Author: | Taberna, Miren Mena Cervigón, Marisa Tous, Sara Pavón Ribas, Miquel Àngel Oliva, Marc León, Xavier Garcia, Jacinto Guix, Marta Hijano, Rafael Bonfill, Teresa Aguilà, Anton Alemany i Vilches, Laia Mesía Nin, Ricard |
Keywords: | Papil·lomavirus Càncer de coll Papillomaviruses Neck cancer |
Issue Date: | 17-Apr-2018 |
Publisher: | Public Library Science |
Abstract: | Background Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8 th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. Material and methods The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7 th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16(INK4a) or HPV-mRNA), p16(INK4a) positivity alone or the combination of HPV-DNA/p16(INK4a) positivity as diagnostic tests. Results A total of 788 consecutive OPC cases diagnosed from 1991 to 2013 were considered eligible for the analysis. Of these samples, 66 (8.4%) were positive for HPV-DNA and (p16(INK4a) or HPV-mRNA), 83 (10.5%) were p16(INK4a) positive and 58 (7.4%) were double positive for HPV-DNA/p16(INK4a). ICON-S model was the staging system, which performed better in our series when using at least two biomarkers to define HPV-causality. When the same analysis was performed considering only p16(INK4a)-positivity, RPA stage with non-anatomic factors (Princess Margaret) has the best classification based on AIC criteria. Conclusion HPV-relatedness definition for classifying HPV-related OPC patient do impact on TNM classification and patients' survival. Further studies assessing HPV-relatedness definitions are warranted to better classify HPV-related OPC patients in the era of de-escalation clinical trials. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0194107 |
It is part of: | Plos One, 2018, Vol. 13, Issue 4: e0194107 |
URI: | http://hdl.handle.net/2445/123919 |
Related resource: | https://doi.org/10.1371/journal.pone.0194107 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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TabernaM.pdf | 2.32 MB | Adobe PDF | View/Open |
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