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Title: | Replication Study Of Polymorphisms Associated With Response To Methotrexate In Patients With Rheumatoid Arthritis |
Author: | López-Rodríguez, Rosario Ferreiro-Iglesias, Aida Lima, Aurea Bernardes, Miguel Pawlik, Andrzej Paradowska-Gorycka, Agnieszka Swierkot, Jerzy Slezak, Ryszard Dolzan, Vita González Álvaro, Isidoro Narváez García, Francisco Javier Cáliz, Rafael Perez-Pampin, Eva Mera-Varela, Antonio Vidal-Bralo, Laura Acuña Ochoa, José Gorgonio Conde, Carmen Gomez Reino, Juan J. González, Antonio |
Keywords: | Metotrexat Artritis reumatoide Polimorfisme genètic Methotrexate Rheumatoid arthritis Genetic polymorphisms |
Issue Date: | 9-May-2018 |
Publisher: | Nature Publishing Group |
Abstract: | About 70 genetic studies have already addressed the need of biomarkers to predict the response of patients with rheumatoid arthritis (RA) to methotrexate (MTX) treatment. However, no genetic biomarker has yet been sufficiently validated. Here, we aimed to replicate a selection of 25 SNPs in the largest collection of patients up to date, which consisted of 915 patients treated with MTX. The change in disease activity (measured as.DAS28) from baseline was considered the primary outcome. In addition, response according to widely used criteria (EULAR) was taken as secondary outcome. We considered consistency between outcomes, P values accounting for the number of SNPs, and independence from potential confounders for interpretation of the results. Only the rs1801394 SNP in MTRR fulfilled the high association standards. Its minor allele was associated with less improvement than the major allele according to.DAS28 (p = 0.0016), and EULAR response (p = 0.004), with independence of sex, age, baseline DAS28, smoking, seropositivity, concomitant corticosteroid use or previous treatments. In addition, previous evidence suggests the association of this SNP with response to MTX in another autoimmune disease, juvenile idiopathic arthritis, and with high intracellular folate levels, which could contribute to poor response. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-25634-y |
It is part of: | Scientific Reports, 2018, Vol. 8:7342 |
URI: | http://hdl.handle.net/2445/123924 |
Related resource: | https://doi.org/10.1038/s41598-018-25634-y |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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