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Title: Genetic Contributions To The Association Between Adult Height And Head And Neck Cancer: A Mendelian Randomization Analysis
Author: Pastorino, Roberta
Puggina, Anna
Carreras-Torres, Robert
Lagiou, Pagona
Holcatova, Ivana
Richiardi, Lorenzo
Kjaerheim, Kristina
Agudo, Antonio
Castellsagué, Xavier
Macfarlane, Tatiana V.
Barzan, Luigi
Canova, Cristina
Thakker, Nalin S.
Conway, David I.
Znaor, Ariana
Healy, Claire M.
Ahrens, Wolfgang
Zaridze, David
Szeszenia-Dabrowska, Neonilia
Lissowska, Jolanta
Fabianova, Eleonora
Mates, Ioan Nicolae
Bencko, Vladimir
Foretova, Lenka
Janout, Vladimir
Brennan, Paul
Gaborieau, Valèrie
Mckay, James D.
Boccia, Stefania
Keywords: Càncer de coll
Creixement humà
Neck cancer
Human growth
Issue Date: 14-Mar-2018
Publisher: Nature Publishing Group
Abstract: With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95% CI), 0.99-1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69-0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.
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It is part of: Scientific Reports, 2018, Vol. 8: 4534
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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