Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/124034
Title: Progression-free survival at 2 years post-autologous transplant: a surrogate end point for overall survival in follicular lymphoma
Author: Jiménez Ubieto, Ana
Grande, Carlos
Caballero, Dolores
Yáñez, Lucrecia
Novelli, Silvana
Hernández, Miguel T.
Manzanares, María
Arranz, Reyes
Ferreiro, José Javier
Bobillo, Sabela
Mercadal, Santiago
Galego, Andrea
López Jiménez, Javier
Moraleda, José María
Vallejo, Carlos
Albo, Carmen
Pérez, Elena
Marrero, Carmen
Magnano, Laura
Palomera, Luis
Jarque, Isidro
Coria, Erika
Rodriguez, Antonia
Martín, Alejandro
López Guillermo, Armando
Salar, Antonio
Lahuerta, Juan José
GELTAMO (Grupo Español de Linfomas y Trasplantes de Médula Ósea)
Keywords: Limfomes
Cèl·lules mare
Lymphomas
Stem cells
Issue Date: 1-Dec-2017
Publisher: Wiley
Abstract: Overall survival (OS) is the gold-standard end point for studies evaluating autologous stem cell transplantation (ASCT) in follicular lymphoma (FL), but assessment may be elusive due to the lengthy disease course. We analyzed the validity of two earlier end points, proposed in the setting of first-line chemo-/immunotherapy, as surrogates for OSprogression-free survival (PFS) status at 24months (PFS24) and complete response at 30months (CR30) post-ASCT. We also have investigated the clinical features of patients with early progression after ASCT. Data were available for 626 chemosensitive FL patients who received ASCT between 1989 and 2007. Median follow-up was 12.2years from ASCT. In the PFS24 analysis, 153 (24%) patients progressed within 24months and 447 were alive and progression-free at 24months post-ASCT (26 who died without disease progressions within 24months were excluded). Early progression was associated with shorter OS (hazard ratio [HR], 6.8; P=0.00001). In the subgroup of patients who received an ASCT in the setting or relapse after being exposed to rituximab, the HR was 11.3 (95% CI, 3.9-30.2; P<0.00001). In the CR30 analysis, 183 of 596 (31%) response-evaluable patients progressed/died with 30months post-ASCT. The absence of CR30 was associated with shorter OS (HR, 7.8; P<0.00001), including in patients with prior rituximab (HR, 8.2). PFS24 and CR30 post-ASCT are associated with poor outcomes and should be primary end points. Further research is needed to identify this population to be offered alternative treatments.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1002/cam4.1217
It is part of: Cancer Medicine, 2017, vol. 6, num. 12, p. 2766-2774
URI: http://hdl.handle.net/2445/124034
Related resource: http://dx.doi.org/10.1002/cam4.1217
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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