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DC Field | Value | Language |
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dc.contributor.author | Cortese, Rene | - |
dc.contributor.author | Gileles-Hillel, Alex | - |
dc.contributor.author | Khalyfa, Abdelnaby | - |
dc.contributor.author | Almendros López, Isaac | - |
dc.contributor.author | Akbarpour, Mahzad | - |
dc.contributor.author | Khalyfa, Ahamed A. | - |
dc.contributor.author | Qiao, Zhuanhong | - |
dc.contributor.author | Garcia, Tzintzuni | - |
dc.contributor.author | Andrade, Jorge | - |
dc.contributor.author | Gozal, David | - |
dc.date.accessioned | 2018-09-03T10:54:51Z | - |
dc.date.available | 2018-09-03T10:54:51Z | - |
dc.date.issued | 2017-02-27 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124205 | - |
dc.description.abstract | Obstructive sleep apnea (OSA) affects 8-10% of the population, is characterized by chronic intermittent hypoxia (CIH), and causally associates with cardiovascular morbidities. In CIH-exposed mice, closely mimicking the chronicity of human OSA, increased accumulation and proliferation of pro-inflammatory metabolic M1-like macrophages highly expressing CD36, emerged in aorta. Transcriptomic and MeDIP-seq approaches identified activation of pro-atherogenic pathways involving a complex interplay of histone modifications in functionally-relevant biological pathways, such as inflammation and oxidative stress in aorta macrophages. Discontinuation of CIH did not elicit significant improvements in aorta wall macrophage phenotype. However, CIH-induced aorta changes were absent in CD36 knockout mice, Our results provide mechanistic insights showing that CIH exposures during sleep in absence of concurrent pro-atherogenic settings (i.e., genetic propensity or dietary manipulation) lead to the recruitment of CD36(+)high macrophages to the aortic wall and trigger atherogenesis. Furthermore, long-term CIH-induced changes may not be reversible with usual OSA treatment. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep43648 | - |
dc.relation.ispartof | Scientific Reports, 2017, vol. 7, p. 43648 | - |
dc.relation.uri | https://doi.org/10.1038/srep43648 | - |
dc.rights | cc-by (c) Cortese, Rene et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Síndromes d'apnea del son | - |
dc.subject.classification | Oxigen en l'organisme | - |
dc.subject.classification | Obesitat | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Morbiditat | - |
dc.subject.classification | Malalties cardiovasculars | - |
dc.subject.other | Sleep apnea syndromes | - |
dc.subject.other | Oxygen in the body | - |
dc.subject.other | Obesity | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Morbidity | - |
dc.subject.other | Cardiovascular diseases | - |
dc.title | Aorta macrophage inflammatory and epigenetic changes in a murine model of obstructive sleep apnea: Potential role of CD36 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 678321 | - |
dc.date.updated | 2018-09-03T10:54:51Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28240319 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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678321.pdf | 1.81 MB | Adobe PDF | View/Open |
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