Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/124230
Title: Adenosine a(1)-a(2a) Receptor Heteromer As A Possible Target For Early-onset Parkinson's Disease
Author: Fernández Dueñas, Víctor
Pérez Arevalo, Andrea
Altafaj, Xavier
Ferré, Sergi
Ciruela Alférez, Francisco
Keywords: Malaltia de Parkinson
Adenosina
Parkinson's disease
Adenosine
Issue Date: 22-Nov-2017
Publisher: Frontiers Media
Abstract: Parkinson's disease (PD) is a progressive, neurodegenerative disorder that affects ~1% of individuals over the age of 60, which turns to 5% in subjects up to 85 years (de Lau and Breteler, 2006). On the other hand, a form of PD, called early-onset PD (EOPD), arises at an earlier age (<45; Bonifati et al., 2005; Ylikotila et al., 2015). EOPD patients generally display a slower progression of the disease and present a better response to dopaminergic treatments; however, they may finally develop a full PD symptomatology (i.e., bradykinesia, resting tremor, muscular rigidity and postural instability, drug-induced dyskinesia; Olgiati et al., 2016).
Note: Reproducció del document publicat a: https://doi.org/10.3389/fnins.2017.00652
It is part of: Frontiers in Neuroscience, 2017, vol. 11
URI: http://hdl.handle.net/2445/124230
Related resource: https://doi.org/10.3389/fnins.2017.00652
Appears in Collections:Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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